2018 Uruguay Open – Singles

Pablo Cuevas was the defending champion but lost in the first round to Mario Vilella Martínez.

Guido Pella won the title after defeating Carlos Berlocq 6–3, 3–6, 6–1 in the final.

Seeds
• # Pablo Cuevas (first round)

• # 🇦🇷 Guido Pella (champion)

• # 🇦🇷 Guido Andreozzi (second round)

• # 🇪🇸 Pablo Andújar (second round)

• # 🇧🇷 Thiago Monteiro (second round)

• # 🇧🇴 Hugo Dellien (second round)

• # 🇮🇹 Paolo Lorenzi (second round)

• # 🇦🇷 Juan Ignacio Londero (first round)