2018 Visit Panamá Cup – Singles

Rogério Dutra Silva was the defending champion but lost in the first round to Evan Song.

Carlos Berlocq won the title after defeating Blaž Rola 6–2, 6–0 in the final.

Seeds
• # 🇷🇸 Dušan Lajović (withdrew)

• # 🇧🇷 Rogério Dutra Silva (first round)

• # 🇩🇪 Yannick Hanfmann (quarterfinals)

• # 🇦🇷 Carlos Berlocq (champion)

• # Darian King (first round)

• # 🇦🇷 Renzo Olivo (second round)

• # 🇺🇸 Reilly Opelka (first round)

• # 🇺🇸 Mitchell Krueger (second round)