2018 Wimbledon Championships – Women's singles

Angelique Kerber defeated Serena Williams in the final, 6–3, 6–3 to win the ladies' singles tennis title at the 2018 Wimbledon Championships. It was her first Wimbledon title and third major singles title overall. She became the first German to win the title since Steffi Graf in 1996. She lost only one set during the tournament, to Claire Liu in the second round. Williams was attempting to equal Margaret Court's all-time record of 24 major singles titles, and to become the first mother to win a major singles title since Kim Clijsters won the 2011 Australian Open.

Garbiñe Muguruza was the defending champion, but lost in the second round to Alison Van Uytvanck.

Simona Halep, Caroline Wozniacki and Sloane Stephens were in contention for the WTA No. 1 singles ranking. Despite losing in the third round, Halep retained the No. 1 ranking after Wozniacki and Stephens lost in the second and first rounds, respectively.

With each of the top ten seeds losing before the quarterfinals, it was the worst overall Wimbledon performance of the top ten women's seeds in the Open Era. This was also the first time in the Open Era that none of the top four women's singles seeds reached the fourth round at Wimbledon.

Seeds
• 🇷🇴 Simona Halep (third round)

• Caroline Wozniacki (second round)

• 🇪🇸 Garbiñe Muguruza (second round)

• 🇺🇸 Sloane Stephens (first round)

• 🇺🇦 Elina Svitolina (first round)

• 🇫🇷 Caroline Garcia (first round)

• 🇨🇿 Karolína Plíšková (fourth round)

• 🇨🇿 Petra Kvitová (first round)

• 🇺🇸 Venus Williams (third round)

• 🇺🇸 Madison Keys (third round)

• 🇩🇪 Angelique Kerber (champion)

•  Jeļena Ostapenko (semifinals)

• 🇩🇪 Julia Görges (semifinals)

• 🇷🇺 Daria Kasatkina (quarterfinals)

• 🇧🇪 Elise Mertens (third round)

• 🇺🇸 CoCo Vandeweghe (first round)

• 🇦🇺 Ashleigh Barty (third round)

• 🇯🇵 Naomi Osaka (third round)

• 🇸🇰 Magdaléna Rybáriková (first round)

•  Kiki Bertens (quarterfinals)

•  Anastasija Sevastova (first round)

• 🇬🇧 Johanna Konta (second round)

• 🇨🇿 Barbora Strýcová (third round)

• 🇷🇺 Maria Sharapova (first round)

• 🇺🇸 Serena Williams (final)

• 🇦🇺 Daria Gavrilova (third round)

• 🇪🇸 Carla Suárez Navarro (third round)

• 🇪🇪 Anett Kontaveit (third round)

• 🇷🇴 Mihaela Buzărnescu (third round)

• 🇷🇺 Anastasia Pavlyuchenkova (first round)

• 🇨🇳 Zhang Shuai (first round)

• 🇵🇱 Agnieszka Radwańska (second round)