2018 Winston-Salem Open

The 2018 Winston-Salem Open was a men's tennis tournament played on outdoor hard courts. It was the 50th edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and part of the ATP World Tour 250 Series of the 2018 ATP World Tour. It took place at Wake Forest University in Winston-Salem, North Carolina, United States, from August 19 through August 25, 2018. It was the last event on the 2018 US Open Series before the 2018 US Open.

Seeds
* Rankings are as of August 13, 2018

Other entrants
The following players received wildcards into the singles main draw:
 * 🇬🇧 Kyle Edmund
 * 🇺🇸 Taylor Fritz
 * Borna Gojo
 * 🇷🇺 Andrey Rublev

The following players received entry from the qualifying draw:
 * 🇲🇩 Radu Albot
 * 🇺🇸 Tommy Paul
 * 🇨🇦 Brayden Schnur
 * 🇦🇷 Horacio Zeballos

The following players received entry as lucky losers:
 * 🇦🇷 Guido Andreozzi
 * 🇩🇪 Dominik Köpfer
 * Franko Škugor

Withdrawals

 * Before the tournament
 * 🇺🇦 Alexandr Dolgopolov → replaced by 🇦🇷 Guido Pella
 * 🇺🇸 Jared Donaldson → replaced by Franko Škugor
 * 🇧🇦 Damir Džumhur → replaced by 🇩🇪 Dominik Köpfer
 * 🇧🇪 David Goffin → replaced by 🇦🇷 Guido Andreozzi
 * 🇰🇿 Mikhail Kukushkin → replaced by 🇷🇸 Laslo Đere
 * 🇪🇸 Feliciano López → replaced by 🇨🇾 Marcos Baghdatis
 * 🇪🇸 Fernando Verdasco → replaced by 🇪🇸 Jaume Munar


 * During the tournament
 * 🇫🇷 Gilles Simon

Seeds

 * Rankings are as of August 13, 2018

Other entrants
The following pairs received wildcards into the doubles main draw:
 * 🇺🇸 James Cerretani / 🇮🇳 Leander Paes
 * 🇦🇺 Lleyton Hewitt / 🇦🇺 John Peers

The following pair received entry as alternates:
 * 🇧🇾 Max Mirnyi / 🇦🇹 Philipp Oswald

Withdrawals

 * Before the tournament
 * 🇦🇺 Lleyton Hewitt

Singles

 * 🇷🇺 Daniil Medvedev def. 🇺🇸 Steve Johnson, 6–4, 6–4

Doubles

 * Jean-Julien Rojer / 🇷🇴 Horia Tecău def. 🇺🇸 James Cerretani / 🇮🇳 Leander Paes, 6–4, 6–2