2018 Winston-Salem Open – Singles

Roberto Bautista Agut was the defending champion, but chose not to participate this year.

Daniil Medvedev won the title, defeating Steve Johnson in the final, 6–4, 6–4.

Seeds
All seeds receive a bye into the second round. • 🇧🇪 David Goffin (withdrew)

• 🇪🇸 Pablo Carreño Busta (semifinals)

• 🇬🇧 Kyle Edmund (quarterfinals)

• 🇮🇹 Marco Cecchinato (second round)

• 🇧🇦 Damir Džumhur (withdrew)

• 🇰🇷 Hyeon Chung (quarterfinals)

• 🇷🇸 Filip Krajinović (third round)

• 🇺🇸 Steve Johnson (final)

• 🇺🇸 Sam Querrey (second round)

• Nikoloz Basilashvili (second round)

• 🇷🇺 Andrey Rublev (second round)

• 🇫🇷 Gilles Simon (withdrew)

• 🇪🇸 Albert Ramos Viñolas (second round)

• Nicolás Jarry (quarterfinals)

• 🇦🇺 Alex de Minaur (second round)

• 🇩🇪 Peter Gojowczyk (third round)

Seeds
• # 🇲🇩 Radu Albot (qualified)

• # 🇦🇺 Jordan Thompson (withdrew)

• # 🇫🇷 Corentin Moutet (first round)

• # 🇦🇷 Guido Andreozzi (qualifying competition, lucky loser)

• # 🇦🇷 Horacio Zeballos (qualified)

• # 🇩🇪 Dominik Köpfer (qualifying competition, lucky loser)

• # 🇨🇦 Brayden Schnur (qualified)

• # 🇦🇹 Maximilian Neuchrist (first round)

Qualifiers
• # 🇲🇩 Radu Albot

• # 🇨🇦 Brayden Schnur

• # 🇦🇷 Horacio Zeballos

• # 🇺🇸 Tommy Paul

Lucky losers
• # 🇦🇷 Guido Andreozzi

• # Franko Škugor

• # 🇩🇪 Dominik Köpfer