2019 Arizona Cardinals season

The 2019 season was the Arizona Cardinals' 100th in the National Football League (NFL), their 32nd in Arizona and their first under head coach Kliff Kingsbury, following the firing of former head coach Steve Wilks the previous season. During the offseason, the Cardinals' home stadium was renamed from University of Phoenix Stadium to State Farm Stadium. The Cardinals were one of two current teams, along with the Chicago Bears, who were among the 14 charter members of the American Professional Football Association, which later became the NFL, that celebrated its 100th season in 2019.

This was also the first season with quarterback Kyler Murray, who was drafted drafted first overall to be the starting quarterback as the Cardinals then traded previous starter Josh Rosen away after just one season. The Cardinals improved on their 3–13 campaign in 2018. However, they were mathematically eliminated from playoff contention for the fourth straight season after a Week 13 loss to the Los Angeles Rams.

Bill Bidwill, who had owned the team since 1972, died on October 2, 2019, at the age of 88.

Draft
Notes
 * As the result of a negative differential of free agent signings and departures that the Cardinals experienced during the free agency period, the team received four compensatory selections for the 2019 draft.

Draft trades
 * The Cardinals traded their seventh-round selection and the rights to former head coach Bruce Arians to the Tampa Bay Buccaneers in exchange for the Buccaneers' sixth-round selection.
 * The Cardinals received a second-round pick from the Miami Dolphins, number 62 overall, and a 2020 fifth-round pick in exchange for quarterback Josh Rosen.

Supplemental draft

The Cardinals selected Washington State safety Jalen Thompson in the fifth round of the 2019 supplemental draft that was held on July 10. As a result, the Cardinals will forfeit their fifth-round selection during the 2020 draft.

Roster changes

In addition to receiving the number one overall draft pick, the Cardinals also have the top spot on the waiver wire by virtue of having the worst record in the NFL during the 2018 season. The Cardinals picked up Pharoh Cooper (wide receiver, previously from the Los Angeles Rams), D. J. Swearinger (safety, previously from the Washington Redskins), Tanner Vallejo (linebacker, previously from the Cleveland Browns), Robert Alford (cornerback, previously from the Atlanta Falcons), Brooks Reed (outside linebacker, previously from the Atlanta Falcons), and Charles Clay (tight end, previously from the Buffalo Bills).

Schedule
Note: Intra-division opponents are in bold text.

Week 11: at San Francisco 49ers
The Cardinals were swept by the 49ers for the first time since 2013.