2019 Brisbane International – Men's singles

Kei Nishikori defeated Daniil Medvedev in the final, 6–4, 3–6, 6–2 to win the men's singles tennis title at the 2019 Brisbane International. The win ended Nishikori's streak of nine consecutive finals lost on the ATP Tour.

Nick Kyrgios was the defending champion, but lost in the second round to Jérémy Chardy.

Seeds
The top four seeds receive a bye into the second round. • # 🇪🇸 Rafael Nadal (withdrew due to injury)

• # 🇯🇵 Kei Nishikori (champion)

• # 🇬🇧 Kyle Edmund (second round)

• # 🇷🇺 Daniil Medvedev (final)

• # 🇨🇦 Milos Raonic (quarterfinals)

• # 🇧🇬 Grigor Dimitrov (quarterfinals)

• # 🇦🇺 Alex de Minaur (quarterfinals)

• # 🇦🇺 Nick Kyrgios (second round)

Seeds
• # 🇺🇸 Bradley Klahn (first round)

• # 🇯🇵 Taro Daniel (qualifying competition, lucky loser)

• # Cristian Garín (qualifying competition)

• # 🇺🇸 Reilly Opelka (first round)

• # 🇫🇷 Ugo Humbert (qualified)

• # 🇨🇦 Peter Polansky (first round)

• # 🇷🇸 Miomir Kecmanović (qualified)

• # 🇺🇸 Bjorn Fratangelo (first round)

Qualifiers
• # 🇫🇷 Ugo Humbert

• # 🇷🇸 Miomir Kecmanović

• # 🇦🇺 Thanasi Kokkinakis

• # 🇯🇵 Yasutaka Uchiyama

Lucky loser
• # 🇯🇵 Taro Daniel