2019 Challenger Ciudad de Guayaquil – Singles

Guido Andreozzi was the defending champion but chose not to defend his title.

Thiago Seyboth Wild won the title after defeating Hugo Dellien 6–4, 6–0 in the final.

Seeds
All seeds receive a bye into the second round. • # 🇧🇴 Hugo Dellien (final)

• # 🇦🇷 Leonardo Mayer (quarterfinals, retired)

• # 🇪🇸 Jaume Munar (third round)

• # 🇧🇷 Thiago Monteiro (second round)

• # 🇸🇰 Andrej Martin (third round)

• # Pedro Sousa (third round)

• # 🇮🇹 Paolo Lorenzi (third round)

• # 🇮🇳 Sumit Nagal (withdrew)

• # 🇦🇷 Federico Coria (semifinals)

• # 🇪🇨 Emilio Gómez (second round)

• # 🇦🇷 Facundo Bagnis (quarterfinals)

• # 🇵🇪 Juan Pablo Varillas (semifinals)

• # 🇸🇰 Jozef Kovalík (third round)

• # 🇪🇸 Mario Vilella Martínez (second round)

• # 🇩🇪 Yannick Hanfmann (quarterfinals)

• # João Domingues (second round)