2019 Charlottesville Men's Pro Challenger – Singles

Tommy Paul was the defending champion but chose not to defend his title.

Vasek Pospisil won the title after defeating Brayden Schnur 7–6(7–2), 3–6, 6–2 in the final.

Seeds
All seeds receive a bye into the second round. • # 🇨🇦 Brayden Schnur (final)

• # Ivo Karlović (second round)

• # 🇺🇸 Denis Kudla (third round)

• # 🇯🇵 Taro Daniel (quarterfinals)

• # 🇺🇸 Marcos Giron (quarterfinals)

• # Blaž Rola (quarterfinals)

• # 🇦🇺 Christopher O'Connell (third round)

• # 🇨🇦 Peter Polansky (second round)

• # Darian King (third round)

• # 🇨🇦 Vasek Pospisil (champion)

• # Mikael Torpegaard (withdrew)

• # 🇫🇷 Maxime Janvier (third round)

• # 🇺🇸 Thai-Son Kwiatkowski (withdrew)

• # 🇷🇺 Alexey Vatutin (second round)

• # 🇺🇸 Mitchell Krueger (third round)

• # 🇰🇿 Dmitry Popko (semifinals)