2019 Copa Sudamericana second stage

The 2019 Copa Sudamericana second stage was played from 21 to 30 May 2019. A total of 32 teams competed in the second stage to decide the 16 places in the final stages of the 2019 Copa Sudamericana.

Draw
 The draw for the second stage was held on 13 May 2019, 20:30 PYT (UTC−4), at the CONMEBOL Convention Centre in Luque, Paraguay. For the second stage, the teams were allocated to two pots according to their previous results in this season: The 32 teams were drawn into 16 ties (O1–O16) between a team from Pot 1 and a team from Pot 2, with the teams from Pot 1 hosting the second leg. Teams from the same association could be drawn into the same tie.
 * Pot 1: 10 teams transferred from the Copa Libertadores and six best winners of the first stage from the Copa Sudamericana
 * Pot 2: 16 remaining winners of the first stage from the Copa Sudamericana

The following were the 10 teams transferred from the Copa Libertadores (two best teams eliminated in the third stage of qualifying and eight third-placed teams in the group stage). 

The following were the 22 winners of the first stage from the Copa Sudamericana. Matches in the first stage were considered for the ranking of teams for the second stage draw.  

Format
 In the second stage, each tie was played on a home-and-away two-legged basis. If tied on aggregate, the away goals rule was used. If still tied, extra time was not played, and a penalty shoot-out was used to determine the winner (Regulations Article 27).

The 16 winners of the second stage advanced to the round of 16 of the final stages.

Matches
The first legs were played on 21–23 May, and the second legs were played on 28–30 May 2019. 


 * }

Match O1
La Equidad won 4–1 on aggregate and advanced to the round of 16 (Match A).

Match O2
Independiente del Valle won 7–3 on aggregate and advanced to the round of 16 (Match B).

Match O3
Fluminense won 4–2 on aggregate and advanced to the round of 16 (Match C).

Match O4
Sporting Cristal won 6–0 on aggregate and advanced to the round of 16 (Match D).

Match O5
Argentinos Juniors won 1–0 on aggregate and advanced to the round of 16 (Match E).

Match O6
Montevideo Wanderers won 1–0 on aggregate and advanced to the round of 16 (Match F).

Match O7
Universidad Católica won 6–0 on aggregate and advanced to the round of 16 (Match G).

Match O8
Tied 1–1 on aggregate, Atlético Mineiro won on penalties and advanced to the round of 16 (Match H).

Match O9
Botafogo won 5–0 on aggregate and advanced to the round of 16 (Match H).

Match O10
Independiente won 4–3 on aggregate and advanced to the round of 16 (Match G).

Match O11
Corinthians won 4–0 on aggregate and advanced to the round of 16 (Match F).

Match O12
Colón won 3–1 on aggregate and advanced to the round of 16 (Match E).

Match O13
Zulia won 3–1 on aggregate and advanced to the round of 16 (Match D).

Match O14
Peñarol won 3–1 on aggregate and advanced to the round of 16 (Match C).

Match O15
Caracas won 2–1 on aggregate and advanced to the round of 16 (Match B).

Match O16
Tied 3–3 on aggregate, Royal Pari won on away goals and advanced to the round of 16 (Match A).