2019 Guangzhou International Women's Open – Singles

Wang Qiang was the defending champion, but lost in the first round to Peng Shuai.

Sofia Kenin won the title, defeating Samantha Stosur in the final, 6–7(4–7), 6–4, 6–2. This marked Stosur's last appearance in a WTA singles final before her retirement in 2022.

Seeds
• #🇺🇦 Elina Svitolina (second round, retired)

• #🇨🇳 Wang Qiang (first round)

• #🇺🇸 Sofia Kenin (champion)

• #🇨🇳 Zhang Shuai (quarterfinals)

• #🇨🇿 Kateřina Siniaková (second round)

• #🇨🇳 Zheng Saisai (second round)

• #🇧🇾 Aliaksandra Sasnovich (first round)

• #🇹🇳 Ons Jabeur (first round)

Seeds
• # 🇨🇳 Zhu Lin (withdrew, still competing in Nanchang)

• # 🇺🇸 Varvara Lepchenko (first round, retired)

• # 🇮🇹 Jasmine Paolini (qualified)

• # 🇨🇿 Tereza Martincová (qualified)

• # 🇷🇸 Nina Stojanović (Received special exempt into main draw)

• # 🇺🇦 Katarina Zavatska (qualified)

• # 🇨🇳 Wang Xiyu (qualifying competition, lucky loser)

• # Dalila Jakupović (qualifying competition, lucky loser)

• # Bibiane Schoofs (first round)

• # 🇧🇪 Yanina Wickmayer (withdrew, still competing in Zhengzhou)

• # 🇺🇸 Sachia Vickery (first round)

• # Lesley Pattinama Kerkhove (qualified)

Qualifiers
• # 🇨🇳 Xun Fangying

• # 🇵🇱 Magdalena Fręch

• # 🇮🇹 Jasmine Paolini

• # 🇨🇿 Tereza Martincová

• # Lesley Pattinama Kerkhove

• # 🇺🇦 Katarina Zavatska

Lucky losers
• # 🇨🇳 Wang Xiyu

• # Dalila Jakupović