2019 Italian Open – Men's singles

Defending champion Rafael Nadal defeated Novak Djokovic in the final, 6–0, 4–6, 6–1 to win the men's singles tennis title at the 2019 Italian Open. It was his record-extending ninth Italian Open title and record 34th ATP Masters 1000 title.

Nick Kyrgios was defaulted from his second round match after multiple penalties for unsportsmanlike conduct. As a result, Kyrgios forfeited all points and prize money earned from the event.

Seeds
The top eight seeds receive a bye into the second round. • 🇷🇸 Novak Djokovic (final)

• 🇪🇸 Rafael Nadal (champion)

• Roger Federer (quarterfinals, withdrew)

• 🇩🇪 Alexander Zverev (second round)

• 🇦🇹 Dominic Thiem (second round)

• 🇯🇵 Kei Nishikori (quarterfinals)

• 🇦🇷 Juan Martín del Potro (quarterfinals)

• Stefanos Tsitsipas (semifinals)

• Marin Čilić (second round)

• 🇮🇹 Fabio Fognini (third round)

• 🇷🇺 Karen Khachanov (third round)

• 🇷🇺 Daniil Medvedev (first round)

• Borna Ćorić (third round)

• Nikoloz Basilashvili (third round)

• 🇫🇷 Gaël Monfils (first round)

• 🇮🇹 Marco Cecchinato (second round)

Seeds
• # 🇷🇸 Dušan Lajović (qualifying competition)

• # 🇫🇷 Benoît Paire (qualified)

• # 🇬🇧 Cameron Norrie (qualified)

• # 🇵🇱 Hubert Hurkacz (first round)

• # 🇧🇦 Damir Džumhur (qualifying competition)

• # 🇪🇸 Jaume Munar (first round)

• # 🇺🇸 Taylor Fritz (qualified)

• # 🇺🇸 Reilly Opelka (qualifying competition)

• # 🇸🇰 Martin Kližan (first round)

• # Robin Haase (first round)

• # 🇯🇵 Yoshihito Nishioka (qualified)

• # 🇳🇴 Casper Ruud (qualified)

• # Nicolás Jarry (qualifying competition)

• # 🇦🇺 Bernard Tomic (qualifying competition)

Qualifiers
• # 🇬🇧 Dan Evans

• # 🇫🇷 Benoît Paire

• # 🇬🇧 Cameron Norrie

• # 🇳🇴 Casper Ruud

• # 🇯🇵 Yoshihito Nishioka

• # 🇪🇸 Albert Ramos Viñolas

• # 🇺🇸 Taylor Fritz