2019 Ladies Open Lugano – Singles

Polona Hercog defeated Iga Świątek in the final, 6–3, 3–6, 6–3 to win the women's singles tennis title at the 2019 Ladies Lugano Open. It was Świątek's first WTA Tour final.

Elise Mertens was the reigning champion, but did not participate.

Seeds
• # Belinda Bencic (first round)

• #🇪🇸 Carla Suárez Navarro (first round)

• #🇸🇰 Viktória Kužmová (second round)

• #🇧🇪 Alison Van Uytvanck (second round)

• #🇫🇷 Pauline Parmentier (first round)

• #🇷🇺 Ekaterina Alexandrova (first round)

• #🇸🇪 Rebecca Peterson (second round)

• #🇧🇾 Vera Lapko (quarterfinals)

Seeds
• # 🇨🇿 Tereza Smitková (moved to main draw)

• # 🇪🇸 Paula Badosa Gibert (qualifying competition, retired)

• # 🇩🇪 Tamara Korpatsch (moved to main draw)

• # 🇧🇬 Viktoriya Tomova (first round)

• # Ekaterine Gorgodze (first round)

• # 🇨🇿 Tereza Martincová (qualifying competition)

• # 🇷🇺 Liudmila Samsonova (first round)

• # 🇺🇦 Katarina Zavatska (qualified)

• # 🇱🇮 Kathinka von Deichmann (first round)

• # 🇩🇪 Antonia Lottner (qualified)

• # 🇵🇱 Magdalena Fręch (qualified)

• # 🇸🇰 Rebecca Šramková (first round)

Qualifiers
• # Clara Tauson

• # 🇺🇦 Katarina Zavatska

• # 🇮🇹 Giulia Gatto-Monticone

• # 🇩🇪 Antonia Lottner

• # 🇵🇱 Magdalena Fręch

• # 🇭🇺 Réka Luca Jani