2019 Las Vegas Challenger – Singles

Thanasi Kokkinakis was the defending champion but chose not to defend his title.

Vasek Pospisil won the title after defeating James Duckworth 7–5, 6–7(11–13), 6–3 in the final.

Seeds
All seeds receive a bye into the second round. • # 🇺🇸 Steve Johnson (quarterfinals)

• # 🇯🇵 Taro Daniel (quarterfinals)

• # 🇺🇸 Marcos Giron (quarterfinals)

• # Blaž Rola (second round)

• # 🇦🇺 James Duckworth (final)

• # 🇪🇨 Emilio Gómez (third round)

• # 🇨🇦 Peter Polansky (second round)

• # Darian King (second round)

• # 🇪🇸 Nicola Kuhn (second round)

• # 🇦🇺 Christopher O'Connell (semifinals)

• # 🇺🇸 Mitchell Krueger (third round)

• # 🇰🇿 Dmitry Popko (third round)

• # 🇺🇸 Jack Sock (second round, retired)

• # Alejandro Tabilo (second round, retired)

• # 🇺🇸 Donald Young (second round)

• # 🇺🇸 J. J. Wolf (second round)