2019 Mississippi Valley State Delta Devils football team

The 2019 Mississippi Valley State Delta Devils football team represented Mississippi Valley State University as a member of the East Division of the Southwestern Athletic Conference (SWAC) during the 2019 NCAA Division I FCS football season. Led by second-year head coach Vincent Dancy, the Delta Devils compiled an overall record of 2–9 and a mark of 1–6 in conference play, placing last out of five teams in the SWAC's East Division. Mississippi Valley State played home games at Rice–Totten Stadium in Itta Bena, Mississippi.

Preseason polls
The SWAC released their preseason poll on July 16, 2019. The Delta Devils were picked to finish in fifth place in the East Division.

Preseason all-SWAC teams
The Delta Devils did not place any players on the preseason all-SWAC teams.