2019 Mutua Madrid Open – Men's singles

Novak Djokovic defeated Stefanos Tsitsipas in the final, 6–3, 6–4 to win the men's singles tennis title at the 2019 Madrid Open. With the win, Djokovic tied Rafael Nadal's record of 33 Masters 1000 singles titles. He did not lose a single set in the entire tournament.

Alexander Zverev was the defending champion, but lost in the quarterfinals to Tsitsipas.

This tournament marked the last professional appearance of David Ferrer; he lost in the second round to Zverev. It was also Roger Federer's first clay court tournament since the 2016 Rome Masters.

Seeds
The top eight seeds received a bye into the second round. • 🇷🇸 Novak Djokovic (champion)

• 🇪🇸 Rafael Nadal (semifinals)

• 🇩🇪 Alexander Zverev (quarterfinals)

• Roger Federer (quarterfinals)

• 🇦🇹 Dominic Thiem (semifinals)

• 🇯🇵 Kei Nishikori (third round)

• 🇦🇷 Juan Martín del Potro (second round)

• Stefanos Tsitsipas (final)

• Marin Čilić (quarterfinals, withdrew due to illness)

• 🇮🇹 Fabio Fognini (third round)

• 🇷🇺 Karen Khachanov (second round)

• 🇷🇺 Daniil Medvedev (first round)

• Borna Ćorić (first round)

• Nikoloz Basilashvili (first round)

• 🇫🇷 Gaël Monfils (third round)

• 🇮🇹 Marco Cecchinato (first round)

Seeds
• # 🇫🇷 Pierre-Hugues Herbert (qualified)

• # 🇫🇷 Benoît Paire (first round)

• # 🇵🇱 Hubert Hurkacz (qualified)

• # 🇧🇦 Damir Džumhur (first round)

• # 🇫🇷 Adrian Mannarino (qualifying competition, lucky loser)

• # 🇺🇸 Mackenzie McDonald (first round)

• # 🇺🇸 Taylor Fritz (qualified)

• # 🇺🇸 Reilly Opelka (qualified)

• # 🇸🇰 Martin Kližan (qualified)

• # 🇦🇷 Leonardo Mayer (first round)

• # Robin Haase (qualifying competition)

• # 🇫🇷 Ugo Humbert (first round)

• # Nicolás Jarry (first round)

• # 🇯🇵 Taro Daniel (first round)

Qualifiers
• # 🇫🇷 Pierre-Hugues Herbert

• # 🇪🇸 Albert Ramos Viñolas

• # 🇵🇱 Hubert Hurkacz

• # 🇧🇴 Hugo Dellien

• # 🇸🇰 Martin Kližan

• # 🇺🇸 Reilly Opelka

• # 🇺🇸 Taylor Fritz

Lucky loser

 * 1) 🇫🇷 Adrian Mannarino