2019 Mutua Madrid Open – Women's singles

Kiki Bertens defeated Simona Halep in the final, 6–4, 6–4 to win the women's singles tennis title at the 2019 Madrid Open. She became the first player to win the title without losing a set en route.

Petra Kvitová was the defending champion, but lost to Bertens in the quarterfinals in a rematch of the previous year's final.

Naomi Osaka, Halep and Angelique Kerber were in contention for the WTA no. 1 singles ranking at the beginning of the tournament. Osaka retained the ranking following Kerber's withdrawal in the second round, and Halep's subsequent defeat in the final.

Seeds
• 🇯🇵 Naomi Osaka (quarterfinals)

• 🇨🇿 Petra Kvitová (quarterfinals)

• 🇷🇴 Simona Halep (final)

• 🇩🇪 Angelique Kerber (second round, withdrew)

• 🇨🇿 Karolína Plíšková (second round)

• 🇺🇦 Elina Svitolina (first round)

• Kiki Bertens (champion)

• 🇺🇸 Sloane Stephens (semifinals)

• 🇦🇺 Ashleigh Barty (quarterfinals)

• 🇧🇾 Aryna Sabalenka (first round)

• Caroline Wozniacki (first round, retired)

• Anastasija Sevastova (third round)

• 🇺🇸 Madison Keys (first round)

• 🇪🇪 Anett Kontaveit (first round)

• 🇨🇳 Wang Qiang (first round)

• 🇩🇪 Julia Görges (first round)

Seeds
• # 🇺🇸 Amanda Anisimova (first round)

• # 🇷🇺 Ekaterina Alexandrova (first round)

• # 🇩🇪 Tatjana Maria (first round)

• # Monica Puig (first round)

• # 🇷🇸 Aleksandra Krunić (first round)

• # 🇫🇷 Kristina Mladenovic (qualified)

• # 🇷🇺 Margarita Gasparyan (qualified)

• # 🇩🇪 Andrea Petkovic (qualifying competition)

• # 🇧🇾 Vera Lapko (first round)

• # Polona Hercog (qualified)

• # 🇸🇰 Magdaléna Rybáriková (first round, retired)

• # 🇷🇺 Anastasia Potapova (qualifying competition)

• # 🇦🇺 Samantha Stosur (first round)

• # 🇷🇺 Veronika Kudermetova (first round)

• # 🇺🇸 Jessica Pegula (qualifying competition)

• # 🇪🇪 Kaia Kanepi (qualifying competition)

Qualifiers
• # 🇺🇦 Marta Kostyuk

• # 🇺🇦 Kateryna Kozlova

• # 🇷🇺 Vera Zvonareva

• # 🇸🇰 Anna Karolína Schmiedlová

• # 🇨🇿 Kristýna Plíšková

• # 🇫🇷 Kristina Mladenovic

• # 🇷🇺 Margarita Gasparyan

• # Polona Hercog