2019 Open Castilla y León – Men's singles

Ugo Humbert was the defending champion but chose not to defend his title.

Nicola Kuhn won the title after defeating Pavel Kotov 6–2, 7–6(7–4) in the final.

Seeds
All seeds receive a bye into the second round. • # Blaž Rola (quarterfinals)

• # Tallon Griekspoor (second round)

• # 🇫🇷 Constant Lestienne (quarterfinals)

• # 🇮🇹 Andrea Arnaboldi (second round)

• # 🇪🇸 Nicola Kuhn (champion)

• # 🇮🇹 Matteo Viola (third round)

• # 🇮🇹 Luca Vanni (second round)

• # 🇫🇷 Kenny de Schepper (second round)

• # 🇪🇸 Roberto Ortega Olmedo (third round)

• # 🇷🇺 Pavel Kotov (final)

• # 🇪🇸 Oriol Roca Batalla (second round)

• # Scott Griekspoor (second round)

• # 🇮🇹 Andrea Vavassori (second round)

• # 🇫🇷 Baptiste Crepatte (third round)

• # 🇺🇿 Khumoyun Sultanov (second round)

• # 🇧🇦 Aldin Šetkić (second round)