2019 Puerto Vallarta Open – Singles

Adrián Menéndez Maceiras was the defending champion but lost in the third round to Lucas Miedler.

Sebastian Ofner won the title after defeating John-Patrick Smith 7–6(10–8), 3–6, 6–3 in the final.

Seeds
All seeds receive a bye into the second round. • # 🇰🇿 Alexander Bublik (second round)

• # 🇪🇸 Adrián Menéndez Maceiras (third round)

• # 🇨🇦 Peter Polansky (third round)

• # 🇩🇪 Dustin Brown (third round)

• # 🇦🇹 Sebastian Ofner (champion)

• # 🇬🇧 James Ward (third round)

• # 🇪🇬 Mohamed Safwat (third round)

• # 🇺🇸 Donald Young (second round)

• # 🇧🇦 Mirza Bašić (semifinals)

• # 🇨🇴 Santiago Giraldo (withdrew)

• # 🇪🇨 Roberto Quiroz (third round)

• # 🇷🇸 Peđa Krstin (second round)

• # Darian King (quarterfinals)

• # 🇦🇺 John-Patrick Smith (final)

• # 🇦🇹 Lucas Miedler (quarterfinals)

• # Blaž Rola (quarterfinals)