2019 Southeast Missouri State Redhawks football team

The 2019 Southeast Missouri State Redhawks football team represented Southeast Missouri State University as a member of the Ohio Valley Conference (OVC) during the 2019 NCAA Division I FCS football season. Led by sixth-year head coach Tom Matukewicz, the Redhawks compiled an overall record of 9–4 with a mark of 7–1 in conference play, sharing the OVC title with Austin Peay. Southeast Missouri State received an at-large bid to the NCAA Division I Football Championship playoffs, where the Redhawks lost to Illinois State in the first round. The team played home games at Houck Stadium in Cape Girardeau, Missouri.

Preseason coaches' poll
The OVC released their preseason coaches' poll on July 22, 2019. The Redhawks were picked to finish in second place.

Preseason All-OVC team
The Redhawks had six players at five positions selected to the preseason all-OVC team.

Offense

Daniel Santacaterina – QB

Kristian Wilkerson – WR

Defense

Clarence Thornton – DL

Zach Hall – LB

Justin Swift – LB

Bydarrius Knighten – DB

Illinois State–NCAA Division I First Round
The Redhawks received an at-large bid to the NCAA Division I Football Championship playoffs, with a first-round pairing against Illinois State.