2019 U.S. Men's Clay Court Championships – Singles

Cristian Garín defeated Casper Ruud in the final, 7–6(7–4), 4–6, 6–3, to win the singles tennis title at the 2019 U.S. Men's Clay Court Championships. The win earned Garín his first career Association of Tennis Professionals (ATP) singles title and made him the first Chilean ATP title holder in ten years. Ruud was also in contention to win his first ATP Tour title after reaching his first final, joining father Christian Ruud as the only two Norwegian players to reach a final at this level.

Steve Johnson was the two-time defending champion, but he lost in the second round to Daniel Elahi Galán.

Seeds
The top four seeds received a bye into the second round. • #🇺🇸 Steve Johnson (second round)

• #🇫🇷 Jérémy Chardy (second round)

• #🇬🇧 Cameron Norrie (second round)

• #🇺🇸 Reilly Opelka (second round)

• #🇺🇸 Taylor Fritz (first round)

• #🇺🇸 Mackenzie McDonald (first round)

• #🇦🇺 Jordan Thompson (quarterfinals)

• #🇺🇸 Sam Querrey (semifinals)

Seeds
• # Henri Laaksonen (qualified)

• # 🇨🇦 Peter Polansky (first round)

• # 🇺🇸 Christopher Eubanks (qualifying competition)

• # 🇦🇹 Sebastian Ofner (first round)

• # 🇺🇸 Mitchell Krueger (qualifying competition)

• # 🇪🇨 Roberto Quiroz (qualifying competition)

• # 🇺🇸 Marcos Giron (first round)

• # 🇬🇧 James Ward (first round)

Qualifiers
• # Henri Laaksonen

• # 🇷🇸 Peđa Krstin

• # 🇨🇴 Santiago Giraldo

• # 🇨🇴 Daniel Elahi Galán