2019 US Open – Girls' singles

Camila Osorio won the girls' singles tennis title at the 2019 US Open, defeating Alexandra Yepifanova 6−1, 6−0 in the final.

Wang Xiyu was the defending champion, but she competed in the women's singles as a lucky loser losing to Kirsten Flipkens in the first round.

Seeds
• 🇺🇸 Emma Navarro (second round)

• 🇫🇷 Diane Parry (first round)

• 🇺🇸 Alexa Noel (third round)

• 🇨🇴 Camila Osorio (champion)

• 🇨🇳 Zheng Qinwen (semifinals)

• 🇯🇵 Natsumi Kawaguchi (first round)

• Kamilla Bartone (quarterfinals)

• 🇺🇸 Hurricane Tyra Black (first round, retired)

• 🇧🇮 Sada Nahimana (first round)

• 🇷🇺 Alina Charaeva (first round)

• 🇹🇭 Mananchaya Sawangkaew (first round)

• 🇰🇷 Park So-hyun (third round)

• 🇺🇸 Abigail Forbes (third round)

• 🇷🇺 Anastasia Tikhonova (first round)

• 🇷🇺 Polina Kudermetova (third round)

• 🇫🇷 Elsa Jacquemot (third round)

Seeds
• # 🇸🇰 Romana Čisovská (qualifying competition, lucky loser)

• # 🇨🇳 Wang Jiaqi (first round)

• # 🇺🇸 Skyler Marie Grace Grishuk (qualified)

• # 🇦🇷 Ana Geller (qualified)

• # 🇨🇳 Han Jiangxue (qualifying competition)

• # 🇧🇷 Ana Luiza Cruz (first round)

• # 🇸🇰 Michaela Kadlečková (qualified)

• # 🇺🇸 Charlotte Owensby (first round)

• # 🇺🇸 Alexandra Yepifanova (qualified)

• # 🇵🇱 Martyna Kubka (qualifying competition)

• # 🇺🇸 Emma Jackson (qualifying competition)

• # 🇯🇵 Funa Kozaki (first round)

• # 🇺🇸 Kailey Evans (qualifying competition)

• # 🇺🇸 Kylie Collins (qualifying competition)

• # Alexandra Eala (qualified)

• # 🇺🇸 Tara Malik (first round)

Qualifiers
• # Alexandra Eala

• # 🇺🇸 Elvina Kalieva

• # 🇺🇸 Skyler Marie Grace Grishuk

• # 🇦🇷 Ana Geller

• # 🇺🇸 Alexandra Yepifanova

• # Carol Young Suh Lee

• # 🇸🇰 Michaela Kadlečková

• # Lauren Anzalotta Kynoch

Lucky loser

 * 1) 🇸🇰 Romana Čisovská