2019 US Open – Men's singles

Rafael Nadal defeated Daniil Medvedev in the final, 7–5, 6–3, 5–7, 4–6, 6–4 to win the men's singles tennis title at the 2019 US Open. It was his fourth US Open title and 19th major title overall. Nadal's victory meant that every major title since the beginning of 2017 had been won by either himself (5), Novak Djokovic (4) or Roger Federer (3). This was the first time since 2006–08 that Djokovic, Federer, and Nadal had claimed all four major singles titles in three consecutive years.

Djokovic was the defending champion, but retired due to a left shoulder injury against Stan Wawrinka in the fourth round. This was the first time since 2006 that Djokovic failed to reach the semifinals (not counting the 2017 tournament, which he missed due to injury).

This marked the first major main-draw appearance for future Australian Open champion Jannik Sinner; he lost to Wawrinka in the first round.

This was the final US Open appearance of five-time champion Federer; he lost in the quarterfinals to Grigor Dimitrov. It was also the last major appearance for 2010 Wimbledon finalist and former world No. 4 Tomáš Berdych.

The respective losses of Wawrinka and Federer in the quarterfinals guaranteed a first-time finalist in the top half of the draw. Medvedev became the second Russian player (after Marat Safin) to reach the final. Medvedev also became the first Russian man to reach a major final since Safin at the 2005 Australian Open.

Dimitrov (ranked 78th) became the lowest-ranked men's singles semifinalist at the US Open since Jimmy Connors (ranked 174th) in 1991. Dimitrov was also the lowest-ranked men's singles semifinalist at any major since Rainer Schüttler (ranked 92nd) at the 2008 Wimbledon Championships.

This was the first time in the Open Era that four quarterfinalists (Federer, Nadal, Wawrinka and Gaël Monfils) were 33 years old or older.

Seeds
All seedings per ATP rankings. • 🇷🇸 Novak Djokovic (fourth round, retired)

• 🇪🇸 Rafael Nadal (champion)

• Roger Federer (quarterfinals)

• 🇦🇹 Dominic Thiem (first round)

• 🇷🇺 Daniil Medvedev (final)

• 🇩🇪 Alexander Zverev (fourth round)

• 🇯🇵 Kei Nishikori (third round)

• Stefanos Tsitsipas (first round)

• 🇷🇺 Karen Khachanov (first round)

• 🇪🇸 Roberto Bautista Agut (first round)

• 🇮🇹 Fabio Fognini (first round)

• Borna Ćorić (second round, withdrew)

• 🇫🇷 Gaël Monfils (quarterfinals)

• 🇺🇸 John Isner (third round)

• 🇧🇪 David Goffin (fourth round)

• Kevin Anderson (withdrew)

• Nikoloz Basilashvili (third round)

• 🇨🇦 Félix Auger-Aliassime (first round)

• 🇦🇷 Guido Pella (first round)

• 🇦🇷 Diego Schwartzman (quarterfinals)

• 🇨🇦 Milos Raonic (withdrew)

• Marin Čilić (fourth round)

• Stan Wawrinka (quarterfinals)

• 🇮🇹 Matteo Berrettini (semifinals)

• 🇫🇷 Lucas Pouille (second round)

• 🇺🇸 Taylor Fritz (first round)

• 🇷🇸 Dušan Lajović (second round)

• 🇦🇺 Nick Kyrgios (third round)

• 🇫🇷 Benoît Paire (second round)

• 🇬🇧 Kyle Edmund (first round)

• Cristian Garín (second round)

• 🇪🇸 Fernando Verdasco (second round)

Championship match ratings
2.751 million viewers on ESPN, in the United States.