2019 Western & Southern Open – Men's singles

Daniil Medvedev defeated David Goffin in the final, 7–6(7–3), 6–4 to win the men's singles tennis title at the 2019 Cincinnati Masters. It was his first ATP Tour Masters 1000 title.

Novak Djokovic was the defending champion, but lost in the semifinals to Medvedev.

Nick Kyrgios set a record for the highest fine in ATP Tour history in his second round loss to Karen Khachanov. He was penalized $113,000 for five separate unsportsmanlike conduct violations including an expletive-laden rant, walking off-court to smash two racquets, and spitting at umpire Fergus Murphy.

Seeds
The top eight seeds receive a bye into the second round. • 🇷🇸 Novak Djokovic (semifinals)

• 🇪🇸 Rafael Nadal (withdrew)

• Roger Federer (third round)

• 🇦🇹 Dominic Thiem (withdrew)

• Stefanos Tsitsipas (second round)

• 🇯🇵 Kei Nishikori (second round)

• 🇩🇪 Alexander Zverev (second round)

• 🇷🇺 Karen Khachanov (third round)

• 🇷🇺 Daniil Medvedev (champion)

• 🇮🇹 Fabio Fognini (withdrew)

• 🇪🇸 Roberto Bautista Agut (quarterfinals)

• Borna Ćorić (first round)

• 🇺🇸 John Isner (second round)

• Marin Čilić (first round)

• Nikoloz Basilashvili (first round)

• 🇧🇪 David Goffin (final)

Seeds
• # 🇰🇿 Mikhail Kukushkin (qualifying competition, lucky loser)

• # João Sousa (qualifying competition, lucky loser)

• # 🇪🇸 Pablo Carreño Busta (qualified)

• # 🇬🇧 Dan Evans (first round)

• # 🇭🇺 Márton Fucsovics (first round)

• # 🇳🇴 Casper Ruud (qualified)

• # 🇷🇸 Miomir Kecmanović (qualified)

• # 🇬🇧 Cameron Norrie (first round)

• # 🇦🇷 Federico Delbonis (qualifying competition, lucky loser)

• # 🇦🇺 John Millman (first round)

• # 🇪🇸 Feliciano López (qualifying competition)

• # 🇷🇺 Andrey Rublev (qualified)

• # 🇰🇿 Alexander Bublik (first round)

• # 🇺🇸 Tennys Sandgren (first round)

Qualifiers
• # 🇷🇺 Andrey Rublev

• # 🇯🇵 Yoshihito Nishioka

• # 🇪🇸 Pablo Carreño Busta

• # Ivo Karlović

• # 🇺🇸 Denis Kudla

• # 🇳🇴 Casper Ruud

• # 🇷🇸 Miomir Kecmanović

Lucky losers
• # 🇰🇿 Mikhail Kukushkin

• # João Sousa

• # 🇦🇷 Federico Delbonis