2019 Winston-Salem Open

The 2019 Winston-Salem Open was a men's tennis tournament played on outdoor hard courts. It was the 51st edition of the Winston-Salem Open (as successor to previous tournaments in New Haven and Long Island), and part of the ATP Tour 250 Series of the 2019 ATP Tour. It took place at Wake Forest University in Winston-Salem, North Carolina, United States, from August 18 through August 24, 2019. It was the last event on the 2019 US Open Series before the 2019 US Open.

Seeds
1 Rankings are as of August 12, 2019

Other entrants
The following players received wildcards into the singles main draw:
 * 🇨🇿 Tomáš Berdych
 * 🇬🇧 Andy Murray
 * 🇨🇦 Denis Shapovalov
 * 🇺🇸 Frances Tiafoe

The following players received entry using a protected ranking into the singles main draw:
 * 🇩🇪 Cedrik-Marcel Stebe
 * 🇮🇱 Amir Weintraub

The following players received entry from the qualifying draw:
 * 🇧🇦 Damir Džumhur
 * 🇺🇸 Bjorn Fratangelo
 * 🇺🇸 Marcos Giron
 * 🇺🇸 Raymond Sarmiento

Withdrawals

 * Nikoloz Basilashvili → replaced by 🇧🇷 Thiago Monteiro
 * Borna Ćorić → replaced by 🇪🇸 Albert Ramos Viñolas
 * Pablo Cuevas → replaced by 🇺🇸 Tennys Sandgren
 * 🇦🇷 Federico Delbonis → replaced by 🇦🇺 Alexei Popyrin
 * 🇧🇴 Hugo Dellien → replaced by 🇮🇳 Prajnesh Gunneswaran
 * 🇺🇸 Bradley Klahn → replaced by 🇪🇸 Jaume Munar
 * 🇸🇰 Jozef Kovalík → replaced by 🇮🇱 Amir Weintraub
 * 🇰🇿 Mikhail Kukushkin → replaced by 🇰🇷 Lee Duck-hee
 * 🇫🇷 Adrian Mannarino → replaced by 🇺🇸 Denis Kudla
 * 🇯🇵 Yoshihito Nishioka → replaced by 🇫🇷 Antoine Hoang

Retirements

 * 🇰🇿 Alexander Bublik ((Injury))
 * 🇫🇷 Jérémy Chardy (Ankle injury)
 * 🇷🇸 Filip Krajinović ((Illness))
 * 🇪🇸 Feliciano López ((Unknown))
 * Lloyd Harris   ((Unknown))

Seeds
1 Rankings are as of August 12, 2019

Other entrants
The following pairs received wildcards into the doubles main draw:
 * 🇮🇱 Jonathan Erlich / 🇮🇳 Leander Paes
 * 🇺🇸 Nicholas Monroe / 🇺🇸 Tennys Sandgren

The following pair received entry as alternates:
 * 🇬🇧 Dan Evans / 🇬🇧 Jonny O'Mara

Withdrawals

 * Ivan Dodig

Singles

 * 🇵🇱 Hubert Hurkacz def. 🇫🇷 Benoît Paire, 6–3, 3–6, 6–3

Doubles

 * 🇵🇱 Łukasz Kubot / 🇧🇷 Marcelo Melo def. 🇺🇸 Nicholas Monroe / 🇺🇸 Tennys Sandgren, 6–7(6–8), 6–1, [10–3]