2019 Winston-Salem Open – Singles

Daniil Medvedev was the defending champion, but chose not to participate this year.

Hubert Hurkacz won his first ATP Tour title, defeating Benoît Paire in the final, 6–3, 3–6, 6–3. Hurkacz became the first Polish man to win a Tour-level singles title since Wojtek Fibak in 1982.

Lee Duck-hee become the first deaf player to win a main draw match on the ATP Tour when he defeated Henri Laaksonen in the first round.

Seeds
All seeds receive a bye into the second round. • 🇫🇷 Benoît Paire (final)

• 🇨🇦 Denis Shapovalov (semifinals)

• 🇵🇱 Hubert Hurkacz (champion)

• João Sousa (second round)

• 🇬🇧 Dan Evans (second round)

• 🇺🇸 Sam Querrey (third round)

• 🇮🇹 Lorenzo Sonego (third round)

• 🇷🇸 Filip Krajinović (third round, retired)

• 🇪🇸 Albert Ramos Viñolas (second round)

• 🇺🇸 Frances Tiafoe (quarterfinals)

• 🇪🇸 Pablo Carreño Busta (quarterfinals)

• 🇳🇴 Casper Ruud (third round)

• 🇷🇸 Miomir Kecmanović (third round)

• 🇦🇺 John Millman (quarterfinals)

• 🇫🇷 Ugo Humbert (third round)

• 🇪🇸 Feliciano López (third round, retired)

Seeds
• # 🇧🇦 Damir Džumhur (qualified)

• # 🇺🇸 Bjorn Fratangelo (qualified)

• # 🇺🇸 Marcos Giron (qualified)

• # 🇺🇸 Christopher Eubanks (first round)

• # 🇨🇦 Filip Peliwo (first round)

• # Marcelo Arévalo (first round)

• # Borna Gojo (qualifying competition)

• # 🇩🇪 Kevin Krawietz (first round)

Qualifiers
• # 🇧🇦 Damir Džumhur

• # 🇺🇸 Bjorn Fratangelo

• # 🇺🇸 Marcos Giron

• # 🇺🇸 Raymond Sarmiento