2020–21 1. FSV Mainz 05 season

The '''2020–21 1. FSV Mainz 05 season''' was the club's 116th season in existence and the club's 12th consecutive season in the top flight of German football. In addition to the domestic league, 1. FSV Mainz 05 participated in this season's edition of the DFB-Pokal. The season covered the period from 1 July 2020 to 30 June 2021.

Matches
The league fixtures were announced on 7 August 2020.

Appearances and goals
! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center| Defenders

! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center| Forwards

! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season