2020–21 C.D. Guadalajara (women) season

The 2020–21 season is Guadalajara's fourth competitive season and fourth season in the Liga MX Femenil, the top flight of Mexican women's football.

Due to the COVID-19 pandemic, Liga MX Femenil's start was delayed for August 2020.

On 23 July 2020, manager Ramón Villa Zevallos was fired due to differences between him and the club's management, regarding the "players' development". He was replaced by Édgar Mejía, who previously played for Guadalajara and achieved a league championship in 2006.

Apertura
{| class="wikitable" style="text-align:center; font-size:100%;" ! style=background-color:#CD1731;color:#FFFFFF| No. ! style=background-color:#CD1731;color:#FFFFFF| Nat. ! style=background-color:#CD1731;color:#FFFFFF| Name ! style=background-color:#CD1731;color:#FFFFFF| Date of birth (Age) ! style=background-color:#CD1731;color:#FFFFFF| Since ! colspan="5" style="background:#02172F; color:#FFFFFF; text-align:center;" | Goalkeepers ! colspan="5" style="background:#02172F; color:#FFFFFF; text-align:center;" | Defenders ! colspan="5" style="background:#02172F; color:#FFFFFF; text-align:center;" | Midfielders ! colspan="5" style="background:#02172F; color:#FFFFFF; text-align:center;" | Forwards
 * 1 || 🇲🇽 || align=left| Celeste Espino || August 9, 2003 || 2019
 * 12 || 🇲🇽 || align=left| Blanca Félix || March 25, 1996 || 2017
 * 25 || 🇲🇽 || align=left| María Fernanda Ayala || April 13, 1997 || 2020
 * 12 || 🇲🇽 || align=left| Blanca Félix || March 25, 1996 || 2017
 * 25 || 🇲🇽 || align=left| María Fernanda Ayala || April 13, 1997 || 2020
 * 25 || 🇲🇽 || align=left| María Fernanda Ayala || April 13, 1997 || 2020
 * 2 || 🇲🇽 || align=left| Jaqueline Rodríguez || September 7, 1996 || 2019
 * 3 || 🇲🇽 || align=left| Miriam García || February 14, 1998 || 2017
 * 4 || 🇲🇽 || align=left| Janelly Farías || February 12, 1990 || 2019
 * 13 || 🇲🇽 || align=left| Daniela Pulido || April 29, 2000 || 2017
 * 14 || 🇲🇽 || align=left| Andrea Sánchez || March 31, 1994 || 2017
 * 16 || 🇲🇽 || align=left| Priscila Padilla || December 11, 1999 || 2017
 * 20 || 🇲🇽 || align=left| Dayana Madrigal || April 23, 2003 || 2020
 * 26 || 🇲🇽 || align=left| Araceli Torres || September 15, 2000 || 2018
 * 27 || 🇲🇽 || align=left| Kinberly Guzmán || September 19, 2002 || 2018
 * 35 || 🇲🇽 || align=left| Damaris Godínez || July 22, 1999 || 2018
 * 16 || 🇲🇽 || align=left| Priscila Padilla || December 11, 1999 || 2017
 * 20 || 🇲🇽 || align=left| Dayana Madrigal || April 23, 2003 || 2020
 * 26 || 🇲🇽 || align=left| Araceli Torres || September 15, 2000 || 2018
 * 27 || 🇲🇽 || align=left| Kinberly Guzmán || September 19, 2002 || 2018
 * 35 || 🇲🇽 || align=left| Damaris Godínez || July 22, 1999 || 2018
 * 26 || 🇲🇽 || align=left| Araceli Torres || September 15, 2000 || 2018
 * 27 || 🇲🇽 || align=left| Kinberly Guzmán || September 19, 2002 || 2018
 * 35 || 🇲🇽 || align=left| Damaris Godínez || July 22, 1999 || 2018
 * 35 || 🇲🇽 || align=left| Damaris Godínez || July 22, 1999 || 2018
 * 35 || 🇲🇽 || align=left| Damaris Godínez || July 22, 1999 || 2018
 * 6 || 🇲🇽 || align=left| Miriam Castillo || June 1, 1992 || 2018
 * 7 || 🇲🇽 || align=left| María Sánchez || February 20, 1996 || 2020
 * 8 || 🇲🇽 || align=left| Nicole Pérez || August 30, 2001 || 2018
 * 10 || 🇲🇽 || align=left| Tania Morales (Captain) || December 22, 1986 || 2017
 * 15 || 🇲🇽 || align=left| Carolina Jaramillo || March 19, 1994 || 2020
 * 18 || 🇲🇽 || align=left| Susan Bejarano || August 7, 1995 || 2017
 * 22 || 🇲🇽 || align=left| Isabella Gutiérrez || March 9, 2004 || 2020
 * 28 || 🇲🇽 || align=left| Michelle González || July 20, 1995 || 2017
 * 30 || 🇲🇽 || align=left| Samara Alcalá || February 27, 1998 || 2019
 * 34 || 🇲🇽 || align=left| Victoria Acevedo || January 16, 1999 || 2017
 * 18 || 🇲🇽 || align=left| Susan Bejarano || August 7, 1995 || 2017
 * 22 || 🇲🇽 || align=left| Isabella Gutiérrez || March 9, 2004 || 2020
 * 28 || 🇲🇽 || align=left| Michelle González || July 20, 1995 || 2017
 * 30 || 🇲🇽 || align=left| Samara Alcalá || February 27, 1998 || 2019
 * 34 || 🇲🇽 || align=left| Victoria Acevedo || January 16, 1999 || 2017
 * 28 || 🇲🇽 || align=left| Michelle González || July 20, 1995 || 2017
 * 30 || 🇲🇽 || align=left| Samara Alcalá || February 27, 1998 || 2019
 * 34 || 🇲🇽 || align=left| Victoria Acevedo || January 16, 1999 || 2017
 * 34 || 🇲🇽 || align=left| Victoria Acevedo || January 16, 1999 || 2017
 * 34 || 🇲🇽 || align=left| Victoria Acevedo || January 16, 1999 || 2017
 * 9 || 🇲🇽 || align=left| Evelyn González || December 5, 1996 || 2020
 * 11 || 🇲🇽 || align=left| Norma Palafox || October 14, 1998 || 2017
 * 17 || 🇲🇽 || align=left| Joseline Montoya || July 3, 2000 || 2019
 * 19 || 🇲🇽 || align=left| Anette Vázquez || March 11, 2002 || 2017
 * 23 || 🇲🇽 || align=left| Guadalupe Velázquez || March 25, 1993 || 2017
 * 24 || 🇲🇽 || align=left| Alicia Cervantes || January 24, 1994 || 2020
 * 29 || 🇲🇽 || align=left| Gabriela Huerta || January 12, 1999 || 2018
 * 31 || 🇲🇽 || align=left| Lía Romero || July 27, 2000 || 2017
 * 33 || 🇲🇽 || align=left| Yashira Barrientos || November 29, 1994 || 2019
 * 23 || 🇲🇽 || align=left| Guadalupe Velázquez || March 25, 1993 || 2017
 * 24 || 🇲🇽 || align=left| Alicia Cervantes || January 24, 1994 || 2020
 * 29 || 🇲🇽 || align=left| Gabriela Huerta || January 12, 1999 || 2018
 * 31 || 🇲🇽 || align=left| Lía Romero || July 27, 2000 || 2017
 * 33 || 🇲🇽 || align=left| Yashira Barrientos || November 29, 1994 || 2019
 * 31 || 🇲🇽 || align=left| Lía Romero || July 27, 2000 || 2017
 * 33 || 🇲🇽 || align=left| Yashira Barrientos || November 29, 1994 || 2019
 * 33 || 🇲🇽 || align=left| Yashira Barrientos || November 29, 1994 || 2019
 * 33 || 🇲🇽 || align=left| Yashira Barrientos || November 29, 1994 || 2019