2020–21 Club América season

The 2020–21 Club América season is the club's 76th consecutive season in the top-flight of Mexican football. The team will participate in the Liga MX and the CONCACAF Champions League.

Squad information
Players and squad numbers last updated on 1 February 2021. Note: Flags indicate national team as has been defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

Pre-season
Club América preceded their 2020–21 campaign by taking part in the Copa por México, being placed in Group A alongside Toluca, UNAM, and Cruz Azul. The matches were announced in June 2020.

2020 CONCACAF Champions League
The 2020 CONCACAF Champions League began during the 2019–20 Liga MX season, but was postponed indefinitely in March due to the COVID-19 pandemic. In November, CONCACAF announced that the remaining fixtures of the Champions League would be held the following month, and would be played at Exploria Stadium in Orlando, Florida.

América, up 3–0 on aggregate, faced Atlanta United in the second-leg of the quarter-finals.

Round of 16
The Round of 16 was played during the 2019–20 Club América season.