2020–21 FC Lokomotiv Moscow season

The 2020–21 FC Lokomotiv Moscow season was the club's 96th season in existence and the club's 25th consecutive season in the top flight of Russian football. In addition to the domestic league, Lokomotiv Moscow participated in this season's editions of the Russian Cup, the Russian Super Cup, and participated in the UEFA Champions League. The season covered the period from 7 August 2020 to 30 June 2021.

Group stage
The group stage draw was held on 1 October 2020.