2020–21 Mamelodi Sundowns F.C. season

The 2020–21 season is Mamelodi Sundowns's 50th season in existence and 25th consecutive season in the South African Premier Division, the top tier of South African soccer. They will also participate in the Nedbank Cup, the MTN 8 and the CAF Champions League.

First team squad

 * As of 22 November 2020

Nedbank Cup
Mamelodi Sundowns entired the competition in the Round of 32

CAF Champions League
Mamelodi Sundowns entered the competition in the first round

First round
The draw for the First Round was on 9 November 2020.

Group stage
The draw for the group stage was held on 8 January 2021

Appearances
Players with no appearances not included in the list.