2020–21 Southern Miss Lady Eagles basketball team

The 2020–21 Southern Miss Lady Eagles basketball team represented the University of Southern Mississippi during the 2020–21 NCAA Division I women's basketball season. The team was led by seventeenth-year head coach Joye Lee-McNelis, and played their home games at the Reed Green Coliseum in Hattiesburg, Mississippi as a member of Conference USA.

Schedule and results
!colspan=12 style=|Non-conference regular season

!colspan=12 style=|C-USA regular season

!colspan=12 style=| C-USA tournament