2020–21 Spezia Calcio season

The 2020–21 Spezia Calcio season was the club's 115th season in existence and the club's first season in the top flight of Italian football. In addition to the domestic league, Spezia participated in this season's edition of the Coppa Italia. The season covered the period from 3 August 2020 to 30 June 2021.

Overview
Note: Coppa Italia match against Roma originally ended in a 4–2 win.

Matches
The League fixtures were announced on 2 September 2020.

Appearances and goals
! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers

! colspan=14 style=background:#dcdcdc; text-align:center| Defenders

! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders

! colspan=14 style=background:#dcdcdc; text-align:center| Forwards

! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season