2020–21 US Sassuolo Calcio season

The 2020–21 season was the 101st season in the existence of U.S. Sassuolo Calcio and the club's 8th consecutive season in the top flight of Italian football. In addition to the domestic league, Sassuolo participated in this season's edition of the Coppa Italia. The season covered the period from 3 August 2020 to 30 June 2021.

First-team squad

 * As of 20 September 2020

Matches
The league fixtures were announced on 2 September 2020.

Coppa Italia
The draw for the tournament was held on 8 September 2020. Sassuolo entered in the round of 16.

Appearances and goals
! colspan=14 style=background:#DCDCDC; text-align:center| Goalkeepers

! colspan=14 style=background:#DCDCDC; text-align:center| Defenders

! colspan=14 style=background:#DCDCDC; text-align:center| Midfielders

! colspan=14 style=background:#DCDCDC; text-align:center| Forwards

! colspan=14 style=background:#DCDCDC; text-align:center| Players transferred out during the season