2020–21 Western Kentucky Lady Toppers basketball team

The 2020–21 Western Kentucky Lady Toppers basketball team represented Western Kentucky University during the 2020–21 NCAA Division I women's basketball season. The team was led by third-year head coach Greg Collins, and played their home games at the E. A. Diddle Arena in Bowling Green, Kentucky as a member of Conference USA.

Schedule and results
!colspan=12 style=|Non-conference regular season

!colspan=12 style=|C-USA regular season

!colspan=12 style=| C-USA tournament