2020–21 Zamalek SC season

The 2020–21 Zamalek SC season was the club's 110th season in existence and the 62nd consecutive season in the top flight of Egyptian football. In addition to the domestic league, Zamalek participated in this season's editions of the Egypt Cup and the CAF Champions League.

Matches
The league fixtures were announced on 23 November 2020.

Qualifying rounds
The draw for the qualifying rounds was held on 9 November 2020.

Group stage
The draw for the group stage was held on 8 January 2021.