2020 Abierto Mexicano Telcel – Men's singles

Nick Kyrgios was the defending champion, but retired from his first round match against Ugo Humbert due to a wrist injury.

Rafael Nadal won the title, defeating Taylor Fritz in the final, 6–3, 6–2. This was the third time that Nadal won the Acapulco Open, and the first time on hard court.

Seeds
• #🇪🇸 Rafael Nadal (champion)

• #🇩🇪 Alexander Zverev (second round)

• # Stan Wawrinka (quarterfinals)

• #🇨🇦 Félix Auger-Aliassime (second round)

• #🇺🇸 John Isner (semifinals)

• #🇦🇺 Nick Kyrgios (first round, retired due to a wrist injury)

• #🇧🇬 Grigor Dimitrov (semifinals)

• #🇷🇸 Dušan Lajović (second round)

Seeds
• # 🇬🇧 Cameron Norrie (Received wildcard into main draw)

• # 🇺🇸 Tommy Paul (qualified)

• # 🇯🇵 Taro Daniel (qualifying competition, lucky loser)

• # 🇧🇦 Damir Džumhur (qualified)

• # 🇺🇸 Marcos Giron (qualified)

• # Jason Jung (qualified)

• # 🇦🇺 Alex Bolt (qualifying competition, lucky loser)

• # 🇨🇴 Daniel Elahi Galán (qualifying competition)

Qualifiers
• # Jason Jung

• # 🇺🇸 Tommy Paul

• # 🇺🇸 Marcos Giron

• # 🇧🇦 Damir Džumhur

Lucky losers
• # 🇦🇺 Alex Bolt

• # 🇯🇵 Taro Daniel