2020 Italian Open – Men's singles

Novak Djokovic defeated Diego Schwartzman in the final, 7–5, 6–3 to win the men's singles tennis title at the 2020 Italian Open. It was his fifth Italian Open title and record 36th Masters 1000 title overall. Djokovic entered his 287th week as world No. 1 (surpassing Pete Sampras in second place) following the tournament.

Rafael Nadal was the two-time defending champion, but lost to Schwartzman in the quarterfinals.

Casper Ruud became the first Norwegian to reach a Masters 1000 semifinal, surpassing his father Christian Ruud, who reached the quarterfinals of Monte Carlo in 1997.

Seeds
The top eight seeds received a bye into the second round. • 🇷🇸 Novak Djokovic (champion)

• 🇪🇸 Rafael Nadal (quarterfinals)

• Stefanos Tsitsipas (second round)

• 🇮🇹 Matteo Berrettini (quarterfinals)

• 🇫🇷 Gaël Monfils (second round)

• 🇧🇪 David Goffin (second round)

• 🇮🇹 Fabio Fognini (second round)

• 🇦🇷 Diego Schwartzman (final)

• 🇷🇺 Andrey Rublev (second round)

• Stan Wawrinka (first round)

• 🇷🇺 Karen Khachanov (first round)

• 🇨🇦 Denis Shapovalov (semifinals)

• 🇨🇦 Milos Raonic (second round)

• Cristian Garín (first round)

• 🇧🇬 Grigor Dimitrov (quarterfinals)

• 🇨🇦 Félix Auger-Aliassime (first round)

The players who also received a bye into the second round were as follows, corresponding each semifinalist from the US Open:
 * 🇪🇸 Pablo Carreño Busta

The other seven byes were removed and therefore seven players were added into the main draw.

Seeds
• # 🇺🇸 Tennys Sandgren (qualified)

• # 🇫🇷 Gilles Simon (second round)

• # Aljaž Bedene (second round)

• # 🇰🇿 Alexander Bublik (moved to main draw)

• # 🇪🇸 Fernando Verdasco (first round)

• # 🇺🇸 Tommy Paul (first round)

• # 🇫🇷 Jérémy Chardy (second round)

• # 🇦🇷 Juan Ignacio Londero (first round)

• # João Sousa (qualifying competition, lucky loser)

• # 🇲🇩 Radu Albot (first round)

• # 🇸🇪 Mikael Ymer (qualifying competition)

• # 🇧🇾 Egor Gerasimov (first round)

• # 🇰🇷 Kwon Soon-woo (first round)

• # 🇬🇧 Cameron Norrie (first round)

• # 🇫🇷 Corentin Moutet (qualifying competition)

• # 🇧🇷 Thiago Monteiro (first round)

Qualifiers
• # 🇺🇸 Tennys Sandgren

• # 🇩🇪 Dominik Koepfer

• # 🇮🇹 Marco Cecchinato

• # 🇮🇹 Lorenzo Musetti

• # 🇦🇷 Federico Coria

• # 🇦🇷 Facundo Bagnis

• # 🇪🇸 Pedro Martínez

• # 🇪🇸 Alejandro Davidovich Fokina

Lucky loser
• # João Sousa