2021–22 1. FSV Mainz 05 season

The 2021–22 season was the 117th season in the existence of 1. FSV Mainz 05 and the club's 13th consecutive season in the top flight of German football. In addition to the domestic league, Mainz participated in this season's edition of the DFB-Pokal.

Matches
The league fixtures were announced on 25 June 2021.