2021–22 ACF Fiorentina season

The 2021–22 season was the 95th season in the existence of ACF Fiorentina and the club's 18th consecutive season in the top flight of Italian football. In addition to the domestic league, Fiorentina participated in this season's edition of the Coppa Italia.

Following last season's disappointment results, Giuseppe Iachini was let go at the end of the season. Gennaro Gattuso was initially hired to be the team's manager in the early summer, but parted ways 23 days after his appointment following disagreements on transfer policy and agent's influence. Vincenzo Italiano was hired from Spezia as the team's next manager.

Squad information

 * Appearances include league matches only

Matches
The league fixtures were announced on 14 July 2021.

Appearances and goals
! colspan=14 style="background:#9400D3; color:#FFFFFF; text-align:center"| Goalkeepers

! colspan=14 style="background:#9400D3; color:#FFFFFF; text-align:center"| Defenders

! colspan=14 style="background:#9400D3; color:#FFFFFF; text-align:center"| Midfielders

! colspan=14 style="background:#9400D3; color:#FFFFFF; text-align:center"| Forwards

! colspan=14 style="background:#9400D3; color:#FFFFFF; text-align:center"| Players transferred out during the season