2021–22 AC Sparta Prague season

The 2021–22 season was the 128th season in the existence of AC Sparta Prague and the club's 29th consecutive season in the top flight of Czech football. In addition to the domestic league, Sparta Prague participated in this season's editions of the Czech Cup, the UEFA Champions League, the UEFA Europa League, and the UEFA Europa Conference League.

Second qualifying round
The draw for the second qualifying round was held on 16 June 2021.

Third qualifying round
The draw for the third qualifying round was held on 19 July 2021.