2021–22 AFC Ajax season

The 2021–22 season was the 122nd season in the existence of AFC Ajax and the club's 66th consecutive season in the top flight of Dutch football. In addition to the domestic league, Ajax participated in this season's edition of the KNVB Cup, the UEFA Champions League and the Johan Cruyff Shield.

Matches
The league fixtures were announced on 11 June 2021.

Group stage
The draw for the group stage was held on 26 August 2021.

Appearances and goals

 * colspan="14"|Players sold or loaned out after the start of the season:
 * colspan="14"|Players sold or loaned out after the start of the season:

Goalscorers
Last updated: 15 May 2022 Source: Competitive matches

Clean sheets
Last updated: 15 May 2022 Source: Competitive matches