2021–22 Atalanta BC season

The 2021–22 season was the 114th season in the existence of Atalanta B.C. and the club's 11th consecutive season in the top flight of Italian football. In addition to the domestic league, Atalanta participated in this season's editions of the Coppa Italia, the UEFA Champions League and the UEFA Europa League.

Matches
The league fixtures were announced on 14 July 2021. This is the first season with an asymmetrical calendar, i.e., the order of fixtures in the second half of the season (ritorno) is different from the that of the first half (andata).

Group stage
The draw for the group stage was held on 26 August 2021.

Knockout round play-offs
The knockout round play-offs draw was held on 13 December 2021. 

Round of 16
The draw for the round of 16 was held on 25 February 2022.

Quarter-finals
The draw for the quarter-finals was held on 18 March 2022.

Appearances and goals
! colspan=14 style=background:#DCDCDC; text-align:center| Goalkeepers

! colspan=14 style=background:#DCDCDC; text-align:center| Defenders

! colspan=14 style=background:#DCDCDC; text-align:center| Midfielders

! colspan=14 style=background:#DCDCDC; text-align:center| Forwards

! colspan=14 style=background:#DCDCDC; text-align:center| Players transferred out during the season