2021–22 Cagliari Calcio season

The 2021–22 season was the 102nd season in the existence of Cagliari Calcio and the club's sixth consecutive season in the top flight of Italian football. In addition to the domestic league, Cagliari participated in this season's edition of the Coppa Italia.

Matches
The league fixtures were announced on 14 July 2021.

Appearances and goals
! colspan=14 style="background:#000080; color:#FF0000; text-align:center| Goalkeepers

! colspan=14 style="background:#000080; color:#FF0000; text-align:center| Defenders

! colspan=14 style="background:#000080; color:#FF0000; text-align:center| Midfielders

! colspan=14 style="background:#000080; color:#FF0000; text-align:center| Forwards

! colspan=14 style="background:#000080; color:#FF0000; text-align:center| Players transferred out during the season