2021–22 Club América season

The 2021–22 Club América season is the club's 77th consecutive season in the top-flight of Mexican football. The team will participate in the Liga MX.

Coaching staff
Source: Club América

Squad information
Players and squad numbers last updated on 26 January 2022. Note: Flags indicate national team as has been defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

Pre-season and friendlies
Club América preceded their 2021–22 campaign by taking part in the "Tour Águila" in the United States, and mid-season friendlies against Guadalajara and Pumas UNAM.

2021 CONCACAF Champions League
The 2021 CONCACAF Champions League began during the 2020–21 Liga MX season.

Round of 16
The round of 16 was played during the 2020–21 season.

Quarter-finals
The quarter-final was played during the 2020–21 season.