2021–22 Coppa Italia

The 2021–22 Coppa Italia (branded as the Coppa Italia Frecciarossa for sponsorship reasons from the second round) was the 75th edition of the national domestic tournament.

The number of participating teams was reduced from the 78 of the previous season to 44 clubs.

Juventus were the defending champions. They were defeated 4–2 by Internazionale in the final after extra time; it was Inter's eighth Coppa Italia title, having won their seventh cup title in 2011.

Format and seeding
Teams entered the competition at various stages, as follows:
 * First phase (one-legged fixtures)
 * Preliminary round: four teams from Serie C and 4 Serie B teams started the tournament
 * Round of 64: the four winners were joined by 16 Serie B teams and 12 teams from Serie A
 * Round of 32: the 16 winners faced each other
 * Second phase
 * Round of 16 (one-legged): the eight winners were joined by Serie A clubs, seeded 1–8
 * Quarter-finals (one-legged): the eight winners faced each other
 * Semi-finals (two-legged): the four winners faced each other
 * Final (one-legged): the two winners faced each other

Round dates
The schedule of each round was announced on 12 July 2021.

Preliminary round
A total of 8 teams from Serie B and Serie C competed in this round, 4 of which advanced to the first round. Date and time were released on 21 July 2021.

Round of 64
A total of 32 teams (4 winners from the preliminary round, the remaining 16 teams from Serie B and 12 Serie A teams seeded 9–20) competed in this round, 16 of which advanced to the second round.

Round of 32
The 16 winning teams from the first round competed in the second round, 8 of which advanced to the round of 16.

Round of 16
The round of 16 matches were played between the eight winners from the second round and clubs seeded 1–8 in 2020–21 Serie A.

Lecce were the only Serie B club in this round.

Quarter-finals
The quarter-final matches were played between clubs advancing from the round of 16.

Semi-finals
Semi-finals (a two-legged round) were played between clubs advancing from the quarter-finals.