2021–22 Coppa Italia Serie C

The 2021–22 Coppa Italia Serie C was the 49th season of the Coppa Italia Serie C, the cup competition for Serie C clubs.

Juventus U23 were the defending champions having won their first title in June 2020 against Ternana, with a 2–1 final score in the final.

The 2020–21 season was not held due to the COVID-19 pandemic.

Group A (20 teams)

 * AlbinoLeffe
 * FeralpiSalò
 * Fiorenzuola
 * Giana Erminio
 * Juventus U23
 * Lecco
 * Legnago
 * Mantova
 * Padova
 * Pergolettese
 * Piacenza
 * Pro Patria
 * Pro Sesto
 * Pro Vercelli
 * Renate
 * Seregno
 * Südtirol
 * Trento
 * Triestina
 * Virtus Verona

Group B (20 teams)

 * Ancona-Matelica
 * Carrarese
 * Cesena
 * Fermana
 * Grosseto
 * Gubbio
 * Imolese
 * Lucchese
 * Modena
 * Montevarchi
 * Olbia
 * Pescara
 * Pistoiese
 * Pontedera
 * Reggiana
 * Siena
 * Teramo
 * Virtus Entella
 * Vis Pesaro
 * Viterbese

Group C (20 teams)

 * ACR Messina
 * Avellino
 * Bari
 * Campobasso
 * Catania
 * Catanzaro
 * Fidelis Andria
 * Foggia
 * Juve Stabia
 * Latina
 * Monopoli
 * Monterosi
 * Paganese
 * Palermo
 * Picerno
 * Potenza
 * Taranto
 * Turris
 * Vibonese
 * Virtus Francavilla

Format and seeding
The 60 teams in the 2021–22 Serie C entered the competition at various stages, as follows:


 * First phase (one-legged fixtures)
 * First round (one-legged): it is contested by the 56 teams who do not participate in the Coppa Italia.
 * Second round (one-legged): it is contested by the 28 winners of the first round and the four teams that participate in Coppa Italia.
 * Second phase
 * Round of 16 (one-legged): it is contested by the 16 winners of the second round.
 * Quarter-finals (one-legged)
 * Semi-finals (two-legged)
 * Final (two-legged)

Round dates
The schedule of each rounds were announced on 27 July 2021.

First round
The draw was made on 9 August 2021.

Second round
The round is contested by the winners of the previous round and the four teams that participated in the 2021–22 Coppa Italia.

Goalscorers
Statistics include the goals scored by Pro Patria and Lucchese against FeralpiSalò and Legnago, for a total of 154 goals.