2021–22 Coppa Italia Serie D

The 2021−22 Coppa Italia Serie D was the 22nd edition of Coppa Italia Serie D.

Format and seeding
The teams enter the competition at various stage, as follows.


 * First stage
 * Preliminary round: it is contested by 88 teams
 * First round: the 44 winners of the preliminary round and the 84 teams who did not play the preliminary round face each other
 * Final stage
 * Round of 64: the 64 winners face each other
 * Round of 32: the 32 winners face each other
 * Round of 16: the 16 winners face each other
 * Quarter-finals: the 8 winners face each other
 * Semi-finals: the 4 winners face each other
 * Final: the 2 winners face each other