2021–22 Cypriot Cup

The 2021–22 Cypriot Cup was the 80th edition of the Cypriot Cup. A total of 23 clubs entered the competition. It began in September 2021 with the first round and concluded on 25 May 2022 with the final held at the GSP Stadium. Omonia FC won the Cup for the 15th time and qualified for the 2022–23 Europa League play-off round.

First round
The first round draw took place on 31 August 2021.


 * colspan="5" style="background-color:#D0D0D0" align=center|22 September 2021


 * colspan="5" style="background-color:#D0D0D0" align=center|29 September 2021
 * colspan="5" style="background-color:#D0D0D0" align=center|29 September 2021

Second round
The matches were played between 12 January and 2 March 2022.


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Quarter-finals
The matches were played between 9 March and 13 April 2022.


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Semi-finals
The matches were played on 26 April and 4 May 2022.


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