2021–22 ES Sétif season

In the 2021–22 season, ES Sétif competed in the Ligue 1 for the 52nd season. It was their 26th consecutive season in the top flight of Algerian football. They competed in Ligue 1 and the Champions League.

Squad list
Players and squad numbers last updated on 20 October 2021. Note: Flags indicate national team as has been defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

Overview
{| class="wikitable" style="text-align: center" !rowspan=2|Competition !colspan=8|Record !rowspan=2|Started round !rowspan=2|Final position / round !rowspan=2|First match !rowspan=2|Last match !G !W !D !L !GF !GA !GD !Win %
 * Ligue 1
 * Ligue 1


 * N/A
 * 7th
 * 2 November 2021
 * 17 June 2022
 * Champions League
 * Champions League

! Total
 * First round
 * Semi-finals
 * 11 September 2021
 * 14 May 2022

Matches
The league fixtures were announced on 7 October 2021.

Goalscorers
''Includes all competitive matches. The list is sorted alphabetically by surname when total goals are equal.''